Oxidation Products of Phenolic Thiocolchicines: Ring a Quinones and Dienones

1 May 1998

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 28 (9) , 1585-1591
https://doi.org/10.1080/00397919808006862

Abstract

An improved, highly selective demethylation of thiocolchicine (1) to the diphenol 5 is described. Oxidation of 2 to para-quinone 6 and of 4 and 5 to ortho-quinones 8 and 10 is first reported. Also, 2-demethylthiocolchicine (3) was oxidized to the quinone methide 7.

Keywords

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