MANTEL-HAENSZEL ANALYSES OF LITTER-MATCHED TIME-TO-RESPONSE DATA, WITH MODIFICATIONS FOR RECOVERY OF INTERLITTER INFORMATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (11) , 3863-3868
Abstract
The Mantel-Haenszel procedure for comparing sets of time-to-response data is adaptable to data that can be stratified on other variables. A particular adaptation is one in which rats from the same litter were assigned to different treatment groups, e.g., some to a control group and some to a carcinogen treatment group. The time to response used was that of tumor appearance. Death from other causes was considered a loss to observation. The initial litter-adjusted analysis seemed to have only limited advantages compared to analysis that ignored litters and could be interpreted as suggesting that litter matching was not advantageous. Contributing to the difficulty was the fact that in the litter-matched analysis no further information was forthcoming from the remaining similarly treated animals in a litter when there were no remaining contrastingly treated littermates. Several devices for recovering interlitter information from such remnants and combining it with intralitter information are examined and applied.

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