CC14 administration to strain A/J mice or rats and the arachidonic acid content of their liver microsomal prospholipids.

  • 1 May 1976
    • journal article
    • Vol. 14  (1) , 193-6
Abstract
CC14 administration of Sprague-Dawley male rats causes a significant decrease in the arachidonic acid content of their liver microsomal phospholipids. On the contrary, its administration to strain A/J male mice does not modify the concentration during periods of intoxication up to 24 hr. Since this strain of mice is more susceptible to CC14-induced injury than the rat, results indicate that lipid peroxidation can not be the key event in damage induced by this haloalkane.

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