Asymptomatic maternal myasthenia as a cause of the Pena-Shokeir phenotype

Abstract
We report six sibs with arthrogryposis multiplex congenita and a Pena‐Shokeir phenotype, born to a healthy woman who was discovered to have asymptomatic myasthenia gravis (MG). This is the first report of anti‐acetylcholine receptor (AChR) antibodies causing fetal akinesia/hypokinesia sequence in the offspring of an asymptomatic mother. Am. J. Med. Genet. 92:1–6, 2000.