CONCISE REVIEW Biological: Periodontal Inflammation and Insulin Resistance— Lessons from Obesity
- 1 August 2001
- journal article
- review article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 80 (8) , 1690-1694
- https://doi.org/10.1177/00220345010800080201
Abstract
Recent attention has been focused on our understanding of the negative influences of oral chronic inflammation on systemic health. Successful periodontal treatment appears to have beneficial effects on the metabolic control of type 2 diabetes. Although type 2 diabetes is a multiple-risk-factor syndrome, lowered insulin sensitivity, called insulin resistance, is essential in developing the disease. Pro-inflammatory cytokine, tumor necrosis factor-a (TNF-a), produced from adipose tissues in obese subjects, is known to play a predominant role in inducing insulin resistance. Therefore, it can be hypothesized that anti-infectious periodontal treatment may improve metabolic control of diabetes via improved insulin sensitivity by reducing peripheral TNF-a concentration. In this review, we summarize the nature of insulin resistance and discuss the mechanisms by which insulin sensitivity is influenced by chronic inflammation, such as in periodontal disease.Keywords
This publication has 37 references indexed in Scilit:
- The Effect of Antimicrobial Periodontal Treatment on Circulating Tumor Necrosis Factor‐Alpha and Glycated Hemoglobin Level in Patients With Type 2 DiabetesThe Journal of Periodontology, 2001
- Body-Mass Index and Mortality in a Prospective Cohort of U.S. AdultsNew England Journal of Medicine, 1999
- Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin DeficiencyNew England Journal of Medicine, 1999
- Insulin Resistance in Cancer Patients Is Associated with Enhanced Tumor Necrosis Factor-α Expression in Skeletal MuscleBiochemical and Biophysical Research Communications, 1998
- Regulation of GLUT4 mRNA Stability by Tumor Necrosis Factor-α: Alterations in Both Protein Binding to the 3′ Untranslated Region and Initiation of TranslationBiochemical and Biophysical Research Communications, 1996
- IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin ResistanceScience, 1996
- Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db MiceCell, 1996
- Abnormal splicing of the leptin receptor in diabetic miceNature, 1996
- Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.Journal of Clinical Investigation, 1995
- The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasoneJournal of Hepatology, 1988