THE EFFECT OF CORTISONE AND ACTH ON ADRENAL TRANSPLANTS IN THE RAT

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Abstract
SUMMARY: The effect of cortisone and ACTH on auto- and homotransplants of adrenal tissue has been studied in adrenalectomized rats. If the two hormones are administered simultaneously in appropriate dosage the regeneration of autotransplants is not inhibited, but neither ACTH alone nor cortisone and ACTH combined, in various dosages, have any decisive beneficial effect on the survival of homotransplants. A positive Thorn test is of value as an index of the presence of a healthy transplant in the strain of rats employed, but a negative result does not necessarily exclude this. The significance of these findings is discussed.