THE CONCENTRATION OF ARSENIC IN TISSUES AND THE EXCRETION OF ARSENIC BY EXPERIMENTAL ANIMALS FOLLOWING INTRAVENOUS INJECTION OF MASSIVE DOSES OF MAPHARSEN

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Abstract
14 dogs were given intraven. mapharsen (the hemialcoholate of m-amino-p-hydroxy phenylarsenoxide), by continuous drip in doses of 4 mg/kg/day for each of 4 successive days. Small doses of Na pentobarbital were used as anesthetic. Animals were sacrificed at varying intervals during and following treatment and As detd. in the tissues and the tissues examined histologically. Blood As conc., urinary and fecal As excretion were detd. Urinary excretion was approx. 27% and fecal excretion 35% during treatment period. As concs. of approx. 100 [gamma] % of wet tissue were attained at the 4th day in nearly all of 13 tissues examined and tended to follow blood As level with the exception of liver, kidney, and bone (higher), and brain (lower). As was rapidly excreted from most tissues following treatment but the concn. in bone reached the highest level 8 days following treatment. Histological examination showed minimal changes which were interpreted as being entirely reversible.

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