Polypeptide Chains of Antibody: Effective Binding Sites Require Specificity in Combination
- 5 February 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 147 (3658) , 613-615
- https://doi.org/10.1126/science.147.3658.613
Abstract
Separated chains from antibody of different rabbits do not always give effective binding sites although combination of the chains does occur. There is a specificity of combination such that only chains from the same (or perhaps a related) rabbit form effective binding sites. There appears to be preferential combination between those chains which yield effective sites.Keywords
This publication has 9 references indexed in Scilit:
- RECOMBINATION OF ANTIBODY POLYPEPTIDE CHAINS IN THE PRESENCE OF ANTIGENThe Journal of Experimental Medicine, 1964
- RECONSTITUTION OF ANTIPHAGE ANTIBODIES FROM L AND H POLYPEPTIDE CHAINS AND THE FORMATION OF INTERSPECIES MOLECULAR HYBRIDSThe Journal of Experimental Medicine, 1964
- The Subunits of Purified Rabbit Antibody*Biochemistry, 1964
- Resemblance of the Gross Arrangement of Polypeptide Chains in Reconstituted and Native γ-Globulins*Biochemistry, 1964
- Allotypic Specificities of A- and B- Chains of Rabbit Gamma GlobulinScience, 1964
- Multiplicity of Antibody Proteins in Rabbit Anti-p-Azobenzenearsonate SeraThe Journal of Immunology, 1964
- RECONSTITUTION OF IMMUNOLOGIC ACTIVITY BY INTERACTION OF POLYPEPTIDE CHAINS OF ANTIBODIESProceedings of the National Academy of Sciences, 1963
- Nature of the Combining Site of Antibody against a Hapten Bearing a Positive Charge1Journal of the American Chemical Society, 1960
- Heterogeneity and Average Combining Constants of Antibodies from Individual RabbitsThe Journal of Immunology, 1958