Longing for Ligand: Hedgehog, Patched, and Cell Death
- 8 August 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 301 (5634) , 774-776
- https://doi.org/10.1126/science.1088625
Abstract
The hedgehog signaling pathway controls crucial events during development. In a Perspective, Guerrero and Ruiz i Altaba discuss new work ( Thibert et al.) that identifies the Ptc1 receptor for Sonic hedgehog as a crucial modulator of programmed cell death during development of the chick neural tube. Ptc1 joins a cadre of other receptors, called ligand dependence receptors, that induce the programmed cell death of cells bearing them if they remain unoccupied by ligand.Keywords
This publication has 19 references indexed in Scilit:
- Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic HedgehogScience, 2003
- Medulloblastoma Growth Inhibition by Hedgehog Pathway BlockadeScience, 2002
- Hedgehog–GLI signaling and the growth of the brainNature Reviews Neuroscience, 2002
- A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural TubeMolecular Cell, 2001
- Neuronal specification in the spinal cord: inductive signals and transcriptional codesNature Reviews Genetics, 2000
- In Vivo Functions of the Patched ProteinMolecular Cell, 2000
- Cell Death Regulation in DrosophilaThe Journal of cell biology, 2000
- Dual Roles for Patched in Sequestering and Transducing HedgehogCell, 1996
- Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma SyndromePublished by Elsevier ,1996
- Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus SyndromeScience, 1996