Skeletal Uptake of99mTc-Diphosphonate in Relation to Local Bone Blood Flow
- 1 July 1976
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 120 (1) , 121-123
- https://doi.org/10.1148/120.1.121
Abstract
The right/left ratios of tibial uptake of 99mTc-diphosphonate (EHDP) and relative blood flow (based on microsphere distribution) were determined in control rats and rats with a ligated right femoral artery or a healing right tibial fracture. Correlation between 99mTc-EHDP uptake and relative blood flow was highly significant (r [correlation coefficient] = 0.917; P < 0.0001) for relative flow ratios less than 1.7. When the ratio was greater than 1.7, there was little further increase in 99mTc-EHDP uptake. Ligation of the femoral artery in rats with healing fractures resulted in a more marked reduction of blood flow than of 99mTc-EHDP uptake. Regional bone blood flow may be a major determinant of 99mTc-EHDP uptake, although changes in regional tracer extraction efficiency are also important.Keywords
This publication has 1 reference indexed in Scilit:
- Bone blood flow shown with F18 and the positron cameraAmerican Journal of Physiology-Legacy Content, 1965