Anti-AIDS Agents. 46. Anti-HIV Activity of Harman, an Anti-HIV Principle from Symplocos setchuensis, and Its Derivatives
- 22 June 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (7) , 958-960
- https://doi.org/10.1021/np0101189
Abstract
Matairesinol (1) and harman (5), identified from Symplocos setchuensis, were found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluation of 28 derivatives of 5 revealed that compound 19 showed potent activity with EC50 and therapeutic index values of 0.037 μM and 210, respectively.Keywords
This publication has 9 references indexed in Scilit:
- Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridanaJournal of Natural Products, 2000
- Antitumor agents 201.1 Cytotoxicity of harmine and β-carboline analogsBioorganic & Medicinal Chemistry Letters, 1999
- Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related TriterpenoidsJournal of Natural Products, 1998
- (−)-Arctigenin as a Lead Structure for Inhibitors of Human Immunodeficiency Virus Type-1 IntegraseJournal of Medicinal Chemistry, 1996
- Pharmacologically Active Components of Todopon Puok (Fagraea racemosa), a Medicinal Plant from Borneo.CHEMICAL & PHARMACEUTICAL BULLETIN, 1995
- Phenolic lignans from flower buds of Magnolia fargesiiPhytochemistry, 1992
- Lignanolides: NovelIn VitroAnti-HIV Active AgentsPlanta Medica, 1990
- Lignans of Forsythia intermediaPhytochemistry, 1990
- Tracheolospermum. II Lignans from Trachelospermum asiaticum.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986