Cross-Circulation as a Method in the Study of Drug Fixation and Poisoning
- 18 December 1942
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 96 (2503) , 562-563
- https://doi.org/10.1126/science.96.2503.562
Abstract
250 mg. of Na barbital/kg. body wt. was administered to 5 dogs intraven. After 2 hrs. each dog was united to an etherized dog weighing 3 times as much. Cross-circulation lasted for 1 hr., then pairs were separated. The barbital-treated dogs recovered in an avg. time of 27 mins., while similarly treated dogs not cross-circulated required 29 hrs. The expt. was repeated using dogs of equal wt. and giving the first dogs 500 mg. Na barbital/kg. body wt. Both dogs slept over 24 hrs. after separation. Dogs given 500 mg. barbital and not cross-circulated died in 45 to 234 min.This publication has 0 references indexed in Scilit: