Estrogen Receptor and Alpha-Fetoprotein in Human Breast Cancer: Brief Communication 2

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Abstract
Concentrations of estrogen receptor (ER) and α-fetoprotein were determined by dextran-coated charcoal assay and analyzed with Scatchard plots and radioimmunoassay, respectively, in cytosols of 72 human breast cancers. The values for ER ranged from 0 to 340 fmoles/mg cytosol protein. The concentrations of α-fetoprotein, which were low in all tumor cytosols examined, ranged from less than 0.1 to 1.1 ng/mg cytosol protein. No positive relationship was found between ER and α-fetoprotein concentrations. These results show that ER, but not α-fetoprotein, usually accounts for most of the high estrogen-binding capacity in cytosols of human breast cancers.