Novel analogs of enkephalin: identification of functional groups required for biological activity
- 1 October 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (10) , 1113-1122
- https://doi.org/10.1021/jm00184a010
Abstract
Novel tri and tetrapeptide analogs of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the 1st and 4th residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides had significant in vitro opioid-like activity [in guinea pig ileum] indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.This publication has 21 references indexed in Scilit:
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