Cyclosporin A inhibits phorbol ester-induced cellular proliferation and tumor promotion as well as phosphorylation of a 100-kd protein in mouse epidermis
- 1 January 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 8 (2) , 203-207
- https://doi.org/10.1093/carcin/8.2.203
Abstract
Mouse epidermis and HEL30 keratinocytes contain cellular binding sites for the immunosuppressive agent cyclosporin A (CsA). Phorbol ester-induced DNA synthesis and tumor promotion in mouse skin is strongly suppressed by CsA. The anti-tumor effect of CsA is not the consequence of destruction of initiated cells. CsA selectively inhibits the phosphorylation in vitro of a protein with the relative molecular mass of 100 kd in mouse epidermis and HEL30 cytosol. The CsA-suppressible phosphorylation in vitro does not depend on the addition of Ca2+, phosphoilpid and the phorbol ester TPA.This publication has 2 references indexed in Scilit:
- Generation of the arachidonic acid metabolite 8-HETE by extracts of mouse skin treated with phorbol ester in vivo; identification by 1H-n.m.r. and GC-MS spectroscopyCarcinogenesis: Integrative Cancer Research, 1986
- Macrophage-independent activation of helper T cells. I. Production of Interleukin 2.The Journal of Immunology, 1980