Reversible pH Lability of Cross-linked Vault Nanocapsules
- 20 September 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 8 (10) , 3510-3515
- https://doi.org/10.1021/nl080536z
Abstract
Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10 000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.Keywords
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