Elevated Serum Granulocyte Colony-Stimulating Factor Levels in Patients With Active Phase of Sweet Syndrome and Patients With Active Behçet Disease

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Abstract
Sweet syndrome (SS) has been described as a rare but distinct disorder, characterized by 4 clinical features: fever, neutrophilic leukocytosis, sudden onset of asymmetric erythematous, and often-painful skin lesions and dense dermal infiltrates of mature neutrophils without signs of vasculitis. Behçet disease (BD) demonstrates symptoms similar to those of SS, although the incidence and clinical courses of these 2 disorders are different. Peripheral neutrophilia, enhanced neutrophil activity, and dense dermal infiltration of cutaneous lesions have also been noted in both disorders. Neutrophils may play an important role in the pathogenesis of these 2 diseases, as neutrophils are increased in blood and skin lesions.1