Polymorphism of disopyramide
- 1 October 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 28 (10) , 758-761
- https://doi.org/10.1111/j.2042-7158.1976.tb04042.x
Abstract
Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol−1 is calculated for the system. Dissolution and plasma concentrations show no significant differences in bioavailability between the two polymorphs.This publication has 7 references indexed in Scilit:
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