NICKEL SULPHIDE‐INDUCED RHABDOMYOSARCOMATA IN RATS

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Abstract
Fischer rat tumors (59) and 11 Hooded rat tumors induced by i.m. injection of Ni3S2 were examined and their histopathologic and cytologic characteristics studied. Nine of 11 Hooded rat tumors metastasized, whereas 15 of 59 Fischer rat tumors metastasized within 30 days. Histopathological characterization of the Ni3S2-induced tumors was made according to their preponderant cellular constitution. They were grouped into 6 types: well-differentiated rhabdomyosarcomas, poorly-differentiated rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal tumors, leiomyosarcoma-like and fibrosarcoma-like tumors. Of a total of 70, 47 were rhabdomyosarcomas. Tumors with shorter latent periods in Fischer rats and tumors with fleshy and soft texture demonstrated a higher incidence of metastases.