EARLY SYNERGISTIC KILLING OF BETALACTAMIN AND AMINOGLYCOSIDE COMBINATIONS AS OPTIMAL THERAPY OF PSEUDOMONAS-AERUGINOSA INFECTIONS IN PEDIATRIC INTENSIVE-CARE UNIT

  • 1 September 1986
    • journal article
    • research article
    • Vol. 34  (7) , 855-858
Abstract
Morbidity and mortality among children with Pseudomonas aeruginosa infection in Pediatric Intensive Care Unit remain high. Delays in bacterial killing may be responsible for the poor outcome. Antimicrobial sensitivity and timed-killing assays were determined for ticarcillin, azlocillin, piperacillin, cefsulodin, ceftazidime, gentamicin, tobramycin and amikacin alone and in combination against 40 strains of Pseudomonas aeruginosa isolated from blood cultures and tracheal apirate. Antibiotic concentrations used were at clinically achievable level. Non bactericidal effect was observed with each .beta.-lactam alone. However, with the combinations azlocillin or piperacillin or cefsulodin or ceftazidime plus amikacin a bactericidal effect was observed at 4.5 hours.

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