Synthetic studies directed towards the vancomycin carboxylate binding pocket
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1693-1695
- https://doi.org/10.1039/c39920001693
Abstract
The synthesis of the diastereoisomeric lactones 12a and 12b as models for the carboxylate binding pocket of vancomycin is described; the structure of 12a, which corresponds to the diphenyl ether rotamer found in vancomycin, is established by X-ray crystallographic analysis.Keywords
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