Tritiated Digoxin Binding to (Na + + K + )-Activated Adenosine Triphosphatase: Possible Allosteric Site
- 19 April 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 160 (3825) , 323-325
- https://doi.org/10.1126/science.160.3825.323
Abstract
Tritiated H3-digoxin specifically binds to a cardiac (Na+ + K+)-activated adenosine triphosphatase. In the presence of adenosine triphosphate and other nucleoside di- and triphosphates, binding is stimulated by sodium ion, the apparent rate constant being similar to that reported for phosphorus-32 incorporation from adenosine triphosphate and for the adenosine triphosphatase activity. In the presence of magnesium, manganese, inorganic phosphate, or other ions, sodium ion inhibits binding. The data support an allosteric type of sodium-potassium ion pump.This publication has 28 references indexed in Scilit:
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