Effects of OM-853, a Novel Indolonaphthyridine Derivative, on Behavioral Responses in the Forced Swim Test in Rats
Open Access
- 1 January 1993
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 62 (3) , 325-328
- https://doi.org/10.1254/jjp.62.325
Abstract
Influences of drug-induced manipulations of central serotonergic function on lidocaine- and pentylenetetrazol (PTZ)-induced convulsions were examined in mice. Agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-HT) function decreased the incidence of lidocaine-induced convulsions. These treatments had similar influences on the incidence of PTZ-induced convulsions. Lidocaine (10(-5)-10(-3) M) reduced the stimulation evoked [3H]5-HT release from cortical slices, followed with an increased spontaneous [3H] overflow at higher concentrations. These results may suggest that brain 5-HT neurons are causally involved as inhibitory neurons in lidocaine-induced convulsions as in the case of PTZ-induced convulsions.Keywords
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