The absence of antagonism by naloxone during halothane/nitrous oxide anaesthesia in man

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Abstract
Sixteen patients were studied to determine if naloxone could be shown to affect general anaesthesia with halothane and oxygen or nitrous oxide and oxygen with halothane. Changes in blood pressure, pulse rate, electroencephalogram and evidence of physical response were observed. The end-tidal halothane and carbon dioxide were controlled. The temperature and blood gases were held constant, as was the degree of neuromuscular blockade. Naloxone 1.2 mg was administered during general anaesthesia with either halothane in oxygen or halothane with nitrous oxide to 16 patients who were premedicated without a narcotic. No significant responses were recorded. ľobjectif du travail était de déterminer ľeffet du naloxone sur les niveaux ďanesthésie produits par les mélanges halothane-oxygéne et protoxyde ďazote-halothane-oxygéne. Seize patients volontaires ont été soumis à ľétude. On a observé les modifications de la pression artérielle, de la fréquence cardiaque, de ľélectro-encéphalogramme ainsi que les manifestations physiques ďanesthésie légére, ceci aprés atteinte de conditions stables (halothane et CO2 de fin ďexpiration, température, gaz artériels et degré de relâchment musculaire). Une dose de 1.2 mg de naloxone était injectée à ce moment aux patients anesthésiés à ľhalothaneoxygéne et à ceux recevant le mélange protoxyde-oxygéne. Aucune modification significative des paramétres étudiés n’a été observée.