Tumor necrosis factor-α and muscle wasting: a cellular perspective
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Open Access
- 12 July 2001
- journal article
- review article
- Published by Springer Nature in Respiratory Research
- Vol. 2 (5) , 269-72
- https://doi.org/10.1186/rr67
Abstract
Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-alpha on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-alpha disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-kappaB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-alpha effects on skeletal muscle and the mechanism of TNF-alpha action.Keywords
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