rRNA TRANSCRIPTION AND GROWTH RATE–DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI
- 1 October 1996
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 50 (1) , 645-677
- https://doi.org/10.1146/annurev.micro.50.1.645
Abstract
▪ Abstract The synthesis of ribosomal RNA is the rate-limiting step in ribosome synthesis in bacteria. There are multiple mechanisms that determine the rate of rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional strength and for regulation in response to nutritional conditions and amino acid availibility. Strength derives in part from an extended RNA polymerase (RNAP) recognition region involving at least two RNAP subunits, in part from activation by a transcription factor and in part from modification of the transcript by a system that prevents premature termination. Regulation derives from at least two mechanistically distinct systems, growth rate–dependent control and stringent control. The mechanisms contributing to rRNA transcription work together and compensate for one another when individual systems are rendered inoperative.Keywords
This publication has 159 references indexed in Scilit:
- Gene organization and primary structure of a ribosomal RNA operon from Escherichia coliPublished by Elsevier ,2004
- Isolated P2 RRNA Promoters of Escherichia coli are Strong Promoters that are Subject to Stringent ControlJournal of Molecular Biology, 1994
- High Concentrations of ppGpp Decrease the RNA Chain Growth Rate: Implications for Protein Synthesis and Translational Fidelity During Amino Acid Starvation in Escherichia coliJournal of Molecular Biology, 1994
- Factor Independent Activation of rrnB P1Journal of Molecular Biology, 1994
- Post-transcriptional regulation of the str operon in Escherichia coli: Ribosomal protein S7 inhibits coupled translation of S7 but not its independent translationJournal of Molecular Biology, 1994
- Some Base Substitutions in the Leader of an Escherichia coli Ribosomal RNA Operon Affect the Structure and Function of Ribosomes: Evidence for a Transient Scaffold Function of the rRNA LeaderJournal of Molecular Biology, 1993
- Factor-independent activation of Escherichia coli rRNA transcriptionJournal of Molecular Biology, 1991
- Factor-independent activation of Escherichia coli rRNA transcriptionJournal of Molecular Biology, 1991
- Characterization of the guanosine-3′-diphosphate-5′-diphosphate binding site on E.coli RNA polymerase using a photoprobe, 8-Azidoguanosine-3′-5′-bisphosphateBiochemical and Biophysical Research Communications, 1987
- Overall controls on the biosynthesis of ribosomes in growing bacteriaJournal of Theoretical Biology, 1970