The Inhibition of Organic Nitro-Reductase by Aureomycin in Cell-Free Extracts

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Abstract
Aureomycin HC1, in concns. of 10-100 ug./ml., inhibits the reduction to arylamine of the nitro groups of chloramphenicol and p-nitrobenzoic acid by cell-free extracts of Escherichia coli (E-26). Under similar conditions, terramycin has little effect on the reduction. 2,4-dinitrophenol inhibits the reduction of the organic nitro compounds to the same extent as aureomycin. The possible similarity in the underlying mechanism of inhibition by aureomycin and dinitrophenol is being studied.