WY 16225 (DEZOCINE), A NEW SYNTHETIC OPIATE AGONIST-ANTAGONIST AND POTENT ANALGESIC: COMPARISON WITH MORPHINE FOR RELIEF OF PAIN AFTER LOWER ABDOMINAL SURGERY

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Abstract
Dezocine (Wy 16225), a new analgesic was compared randomly and double-blind with morphine 10 mg in 160 female patients complaining of moderate (group I) or severe (group II) pain after elective lower abdominal surgery; both drugs were given i.m. In group I, pain relief with dezocine 10 and 15 mg was significantly greater than dezocine 5 mg; dezocine 10 mg appeared equipotent with morphine 10 mg. Similar, but statistically insignificant differences were observed in group II. Patient sedation was minimal and untoward side-effects infrequent with all doses of the trial drugs.