Knockout Mouse Points to Second Form of Tryptophan Hydroxylase
- 1 March 2003
- journal article
- review article
- Published by CLOCKSS Archive in Molecular Interventions
- Vol. 3 (2) , 72-75
- https://doi.org/10.1124/mi.3.2.72
Abstract
A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1(-/-)mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1(-/-) mice showed no observed behavioral differences from wild-type littermates. Veenstra-Vanderweele and Cook discuss the ramifications of these findings and what they might mean for designing drugs that target the expression and activity of TPH in differing tissues.Keywords
This publication has 0 references indexed in Scilit: