HLA Antigens in Kawasaki Disease
- 1 February 1978
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 61 (2) , 252-255
- https://doi.org/10.1542/peds.61.2.252
Abstract
Two hundred five patients with Kawasaki disease and 500 normal controls were HLA-typed, using a standard microcytotoxicity test of tissue typing. HLA-BW22 was more common in patients with Kawasaki disease than in normal controls (25.4% instead of 11.8%, corrected P < .0005). Among subtypes of HLA-BW22 antigen, Kawasaki disease was associated with HLA-BW22J2, which was found specifically in Japanese and not in Caucasians. These facts may suggest that there is a gene controlling the susceptibility to Kawasaki disease and linked with a Japanese-specific HLA antigen.Keywords
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