Reproductive Function in Epilepsy
- 1 December 1991
- Vol. 32 (s6) , S19-S26
- https://doi.org/10.1111/j.1528-1157.1991.tb05887.x
Abstract
The hypothalamic-pituitary-gonadal axis is a complex system within which both positive and negative feedback occur among its elements and higher brain systems. The occurrence of seizures and changes in the secretion of pituitary hormones can affect the feedback loop. Both seizures and antiepileptic drugs can affect the hypothalamic-pituitary-gonadal axis of males and females and cause changes in hormones and sexuality. Reproductive dysfunction has a social impact because of reduced fertility. Once conception occurs, live birth rates are not diminished. Prospective studies of men and women with epilepsy are needed.Keywords
This publication has 40 references indexed in Scilit:
- Use of oral contraceptives by women with epilepsyJAMA, 1986
- Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA ReceptorScience, 1986
- Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsyActa Neurologica Scandinavica, 1984
- Effect of Norethisterone on Seizures Associated with MenstruationEpilepsia, 1983
- Impotence is not always psychogenic. Newer insights into hypothalamic-pituitary-gonadal dysfunctionPublished by American Medical Association (AMA) ,1980
- Do Anticonvulsants Reduce the Efficacy of Oral Contraceptives?Epilepsia, 1979
- Excretion of Valproic Acid into Semen of Rabbits and ManEpilepsia, 1978
- ANTI-EPILEPTIC DRUGS AND FAILURE OF ORAL CONTRACEPTIVESThe Lancet, 1974
- Unplanned pregnancy in an epileptic.BMJ, 1972
- Response of female mice to anticonvulsants after pretreatment with sex steroidsJournal of Pharmacy and Pharmacology, 1970