A DIFFERENTIAL STUDY OF COCCIDIOIDAL GRANULOMA AND BLASTOMYCOSIS

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Abstract
To California physicians who have seen a good deal of a disease peculiar to the San Joaquin Valley and described as coccidioidal granuloma there seems to be a confusion on the part of some writers as to its relation to blastomycosis, and indeed, the two have been frequently referred to as one and the same disease. It is our purpose to show how real the confusion is in the literature, and by describing the morphology of the two organisms, their development and appearance in tissue, as well as the reactions found, and finally by a comparison of the effect of each form on inoculated animals, to show that they are distinctly different and not merely different forms of the same organism with different methods of development and different toxicity under varying conditions. This latter view is held by Wright, who in his article on the subject in Osler's "System

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