STUDIES ON THE BIOLOGIC CHARACTERIZATION OF HUMAN GONADOTROPINS. VII. URINARY GONADOTROPINS OF MEN, POSTMENOPAUSAL WOMEN AND EUNUCHS*

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Abstract
Human pituitary gonadotropin (HPG) was prepared by the kaolin-acetone method from large quantities of urine of normal men, postmenopausal women and eunuchs. These 3 preparations of HPG were studied by a general gonadotropin assay, by assays for FSH and LH, and by the fingerprint system for identification of gonadotropins. The ratio of gonadotropic potency of the HPG preparations from men and postmenopausal women was the same regardless of the methods of assay used, indicating that the proportions of FSH and LH in the HPG from these two sources were the same. However, the HPG from the urine of eunuchs contained more FSH than LH as compared with HPG from the urine of men or postmenopausal women. The FSH/LH ratio in HPG from eunuchs was about twice that of HPG from men or postmenopausal women.