Scanning electron microscopic study on the effect of tunicamycin on Candida albicans
- 1 November 1993
- Vol. 36 (11-12) , 397-403
- https://doi.org/10.1111/j.1439-0507.1993.tb00728.x
Abstract
Scanning electron microscopy was used to study the effect of tunicamycin, an inhibitor of N-glycosylation, on the morphology of Candida albicans grown in minimal essential medium Earle's base and supplemented with 0.5% N-acetyl-D-glucosamine to stimulate germ tube induction. Addition of the drug prevented development of germ tubes, development of mycelia from germ tubes and resumption of germ tube growth after drug removal. Inhibited cells increased in size during treatment and subsequently became misshapen and shrivelled with evidence of cytoplasmic spillage.Keywords
This publication has 14 references indexed in Scilit:
- Formation of a New Cell Wall by Protoplasts of Candida albicans: Effect of Papulacandin B, Tunicamycin and NikkomycinMicrobiology, 1987
- Cell Envelope ofCandida AlbicansCRC Critical Reviews in Microbiology, 1987
- Tunicamycin and papulacandin B inhibit incorporation of specific mannoproteins into the wall of Candida albicans regenerating protoplastsBiochimica et Biophysica Acta (BBA) - General Subjects, 1986
- Effect of papulacandin B and calcofluor white on the incorporation of mannoproteins in the wall of Candida albicans blastosporesBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- Effect of Tunicamycin on Germ Tube and Yeast Bud Formation in Candida albicansMicrobiology, 1985
- An obligatory role of protein glycosylation in the life cycle of yeast cellsFEBS Letters, 1982
- The specific site of tunicamycin inhibition in the formation of dolichol‐bound N‐acetylglucosamine derivativesFEBS Letters, 1976
- Ultrastructural Changes in the Wall during Germ-tube Formation from Blastospores of Candida albicansJournal of General Microbiology, 1973
- Enzyme Activities Associated with Carbohydrate Synthesis and Breakdown in the Yeast and Mycelial Forms of Candida albicansJournal of General Microbiology, 1973
- Cell Wall Composition of the Mycelial and Blastospore Forms of Candida albicansJournal of General Microbiology, 1968