Increased Survival of Experimental Skin Flaps in Rats Following Treatment with Antiadrenergic Drugs

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Abstract
The effect upon the survival of skin flaps of several drugs which affect the adrenergic system was studied in rats. In control animals 41% of the skin flaps had survived seven days after the operation. Reserpine (1 mg/kg) injected intraperioneally (i.p.) three days and one day before the flap operation increased the surviving flap area by 75% (pppp<0.001). The results demonstrated that the survival of skin flaps increased when the function of the adrenergic nervous system was inhibited. Enhanced sympathetic nervous activity slightly reduced or did not affect skin flap survival.