Involvement of Adenosine 3':5'-Cyclic Monophosphate in the Germination of Blastospores of Candida albicans

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Abstract
The germination of blastospores of C. albicans is accompanied by a rise in the intracellular concentration of cAMP. Germination was induced either by peptides isolated from seminal plasma or by an amino acid mixture, and both germination and the rise in cAMP required a temperature of 37.degree. C. The rise occurred during the 1st h of incubation, but full germination required a temperature of 37.degree. C for 4 h. Germination and the rise in cAMP, in the presence of suboptimal concentrations of inducers, were stimulated by theophylline. Preincubation of cells with dithiothreitol in the absence of inducers inhibited subsequent germination but not the rise in cAMP. Germination and the rise in cAMP were inhibited if dithiothreitol or N-succinimidyl-3-(4-hydroxyphenyl)propionate was present during the induction period.

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