Synthesis of Glycopeptides with Partial Structure of Human Glycophorin Using the Fluorenylmethoxycarbonyl/ Allyl Ester Protecting Group Combination

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Abstract
Glycopeptide partial structures of glycophorin A are synthesized with Tn antigen type monosaccharide and T antigen type disaccharide side chains O-glycosidically linked to serine or threonine. The N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) group and the C-terminal allyl ester were used as orthogonally stable, selectively removable protecting groups.