T-Helper Heterogeneity and Immune Response Patterns
- 15 August 1989
- journal article
- research article
- Published by Taylor & Francis in Hospital Practice
- Vol. 24 (8) , 101-133
- https://doi.org/10.1080/21548331.1989.11703766
Abstract
We have long known that helper T cells regulate antibody-dependent humoral responses; we are now beginning to understand how they do so. In murine systems, there are two TH subsets: One secretes IL-2 and γ-interferon, the other IL-4 and IL-5. The helper-subset-specific cytokines affect B cells, and therefore the regulation of antibody secretion, in profoundly different ways.Keywords
This publication has 3 references indexed in Scilit:
- Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.The Journal of Experimental Medicine, 1989
- The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype RegulationImmunological Reviews, 1988
- ‘B-cell factors’ are pleiotropicImmunology Today, 1988