ROLE OF SERUM FACTORS FROM TOLERANT MICE IN BLOCKING AND IN IMMUNOLOGICAL ENHANCEMENT

Publisher Website
Google Scholar
Abstract
SUMMARY Sera from humorally tolerant (HT) and from completely tolerant (CT) B10.D2 mice (tolerant to H-2a antigens) did not block specific lymphoid cell cytotoxicity in a short-term 51Cr release assay. Anti-B10.A hyperimmune antisera and sera from B10.D2 high responders did provide significant blocking in this system. These latter sera, in contrast to sera from tolerant mice, had high titers of cytotoxic antibodies. Those sera that produced blocking also strikingly enhanced the growth of strain A (H-2a) Sarcoma I. Sera from HT or CT mice did not enhance. Preliminary studies were carried out on the blocking capacity of these same sera in a microcytoxicity assay. Blocking of lymphoid cell activity was observed with sera from CT but not from HT mice. The two sera with high cytotoxic antibody titers (hyperimmune and sera from high responders) did not block in this system. These results are discussed in relation to the mechanism of tolerance.

This publication has 0 references indexed in Scilit: