Movable lobes and flexible loops in proteins Structural deformations that control biochemical activity
- 1 July 1993
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 326 (1-3) , 4-10
- https://doi.org/10.1016/0014-5793(93)81749-p
Abstract
Two classes of protein whose structure is modified by small ligands are reviewed. Proteins of one group contain two massive domains joined by a flexible link; in response to small molecules, the two lobes approach and enclose the ligand. In the other, a short segment of amino acids moves as a flexible loop over the ligand which often is trapped in a non‐aqueous environment. Biochemical reaction rates are altered dramatically by these movements.Keywords
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