Increase in choline acetyltransferase activity in surgically isolated postganglionic parasympathetic neurones of the urinary bladder of adult rats

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Abstract
In the urinary bladder of adult male rats the choline acetyltransferase activity in postganglionic neurons isolated from the CNS increased markedly and rapidly following section of the contralateral postganglionic neurons. The enzyme activity of the operated bladder was 32% of the control 3 days postoperatively, while at the last observation, 25 days postoperatively, it was 86%. As judged from additional studies on totally denervated bladders and on totally decentralized bladders the increase found in the enzyme activity was not due to ingrowth of nerves from outside or to unspecific acetylcholine synthesis neither was it due to increase in bladder wall tension or to increase in tissue mass.