EFFECT OF DOSE FRACTIONATION OF DAUNORUBICIN ON SURVIVAL OF LEUKEMIC-CELLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (8) , 2835-2838
Abstract
Mice bearing transplanted AKR leukemia received daunorubicin either as a single dose or as 4 equally divided doses (0.2 mg/mouse; 4 times) with the time interval between the divided doses varying from 12-36 h; survival of leukemia colony-forming cells was then assayed. When daunorubicin was administered in any of the fractionated schedules, the dose-survival curve was exponential with a shoulder region demonstrable. There was significantly less cell killing for the fractionated schedule than for a comparable accumulated single dose. With administration of the 4th dose for any interval studied, the increment in cell killing was so large that it was quite similar to that resulting from a single 0.8-mg/mouse dose. The time course of cell killing for the 24-h fractionation schedule exhibited greater killing than expected after each subsequent dose with the most pronounced increase occurring after the 4th dose. Possible mechanisms for this effect are discussed.

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