Serum Neutralization of Distemper Virus in Chick Embryos.

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Abstract
Summary Virus-neutralization tests were carried out in embryonated hen's eggs employing the egg-adapted distemper virus and various samples of serum. Ferrets whose sera contained no demonstrable antibody at 1:40 dilution all succumbed to 100 MLD of ferret distemper virus, whereas ferrets showing antibody titer to 1:640 dilution of serum all survived the same challenge dose. The data presented demonstrate that the results of serum-neutralization tests in chick embryos have a definite correlation with ferret protection tests. Human gamma globulin and some samples of human serum have neutralizing substances in titers as high as those known to exist in immune ferret serum. On the other hand, samples of serum from normal premature infants did not show any neutralizing substances in 1:40 dilution of the serum.
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