The use of adult rat liver cultures in the detection of the genotoxicity of various polycyclic aromatic hydrocarbons

1 January 1981

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 3 (4) , 477-487
https://doi.org/10.1002/em.2860030408

Abstract

The hepatocyte primary culture (HPC)-DNA repair test and the adult rat liver epithelial cell (ARL)-hypoxanthine-guanine phosphoribosyl transferase (HGPRT) mutagenesis assay are 2 in vitro short-term tests that possess intrinsic capability for xenobiotic biotransformation. Both assays detected the genotoxocity of a variety of carcinogenic polycyclic aromatic hydrocarbons. These 2 tests, which embody intact cellular metabolism, are useful for the evaluation of this class of carcinogens and provide results that strengthen those obtained in tests dependent upon subcellular metabolism.

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