Gas-Liquid Chromatographic Determination of Nikethamide in Injectable Preparations

1 January 1976

journal article
research article
Published by Oxford University Press (OUP) in Journal of AOAC INTERNATIONAL

Vol. 59 (1) , 93-97
https://doi.org/10.1093/jaoac/59.1.93

Abstract

A gas-liquid chromatographic (GLC) method, using a 4% XE-60 on 80-100 mesh Gas-Chrom Q column, a flame ionization detector, and anthracene as the internal standard, has been developed for the direct determination of nikethamide. Eight collaborators analyzed 4 samples, using methanol as the solvent; the coefficients of variation obtained ranged from 1.19 to 3.20%. In a limited study with acetone as the solvent, the coefficients of variation ranged from 0.59 to 1.96%. The GLC method with acetone as a solvent has been adopted as official first action.

This publication has 0 references indexed in Scilit: