Nonedited 1H NMR lactate/n‐acetyl aspartate ratios and the in vivo determination of lactate concentration in brain
- 1 May 1988
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 7 (1) , 95-99
- https://doi.org/10.1002/mrm.1910070111
Abstract
The 1H lactate/n-acetyl aspartate ratio is commonly used for the quantitation of brain lactate under pathological conditions. We demonstrate that the intensity of the lactate methyl region in water-suppressed, nonedited 1H spectra increases following mild brain trauma as a result of factors other than lactate accumulation. © 1988 Academic Press, Inc.This publication has 16 references indexed in Scilit:
- 31P NMR characterization of graded traumatic brain injury in ratsMagnetic Resonance in Medicine, 1988
- In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizureAnnals of Neurology, 1987
- Alterations in Lipid Metabolism, Na+,K+‐ATPase Activity, and Tissue Water Content of Spinal Cord Following Experimental Traumatic InjuryJournal of Neurochemistry, 1987
- 31P and 1H NMR spectroscopy to study the effects of Gallopamil on brain ischemiaMagnetic Resonance in Medicine, 1987
- Combined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline‐induced seizures in vivoAnnals of Neurology, 1986
- Observation of the terminal methyl group in fatty acids of the linolenic series by a new proton NMR pulse sequence providing spectral editing and solvent suppression. Application to excised frog muscle and rat brainBiochemistry, 1986
- NMR Spectroscopy of Brain Metabolism In VivoAnnual Review of Neuroscience, 1986
- A method for lactate detection in vivo by spectral editing without the need for double irradiationJournal of Magnetic Resonance (1969), 1986
- Stimulation of Free Fatty Acid and Diacylglycerol Accumulation in Cerebrum and Cerebellum During Bicuculline‐Induced Status Epilepticus. Effect of Pretreatment with α‐Methyl‐p‐Tyrosine and p‐ChlorophenylalanineJournal of Neurochemistry, 1983
- Homonuclear broadband-decoupled absorption spectra, with linewidths which are independent of the transverse relaxation rateJournal of Magnetic Resonance (1969), 1979