Neuroendocrine Evidence for Reduced Serotonergic Neurotransmission During Heavy Drinking
- 1 August 1994
- journal article
- clinical trial
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 18 (4) , 822-825
- https://doi.org/10.1111/j.1530-0277.1994.tb00045.x
Abstract
A fenfluramine (60-mg oral dose) challenge test was performed in 19 male heavy drinkers (mean daily consumption 88 g of pure alcohol). Twelve healthy males served as controls. The prolactin and temperature responses to fenfluramine were significantly reduced in the group of heavy drinkers. The results suggest impaired central serotonergic neurotransmission in alcoholism, possibly involving subsensitivity in various serotonin receptor subtypes.Keywords
This publication has 16 references indexed in Scilit:
- Cortisol and Prolactin Responses to d-Fenfluramine in Non-depressed Patients with Obsessive-Compulsive Disorder: A Comparison with Depressed and Healthy ControlsThe British Journal of Psychiatry, 1992
- Hormone responses to fenfluramine and placebo challenge in endogenous depressionPsychiatry Research, 1992
- Fenfluramine stimulation of prolactin in obsessive-compulsive disorderPsychiatry Research, 1992
- Effect of Fluoxetine on Alcohol Consumption in Male AlcoholicsAlcohol, Clinical and Experimental Research, 1992
- Sub-types of serotonin receptorsInternational Clinical Psychopharmacology, 1992
- Neuroendocrine responses to serotonergic agents in alcoholicsBiological Psychiatry, 1991
- Hormonal responses to fenfluramine in depressed and control subjectsJournal of Affective Disorders, 1990
- The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholicsLife Sciences, 1988
- 5-Hydroxyindoleacetic acid in cerebrospinal fluid in alcoholic patients under different clinical conditionsAlcohol, 1985
- Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependenceJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1981