Multivariate analysis of an enzymic profile for the differential diagnosis of viral hepatitis.
Open Access
- 1 December 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 26 (13) , 1897-1899
- https://doi.org/10.1093/clinchem/26.13.1897
Abstract
Differential diagnosis of acute viral hepatitis, persistent chronic hepatitis, aggressive chronic hepatitis, and post-necrotic cirrhosis can reasonably be achieved on the basis of three well-known liver-function tests: aspartate aminotransferase, alanine aminotransferase, and glutamate dehydrogenase. With use of principal-component analysis, these four liver diseases can be characterized by two criteria: a “cytolytic” criterion, correlated particularly with a membrane-permeability test—namely, alanine aminotransferase activity—and a “mitochondrial damage” criterion, which is associated with above-normal ornithine carbamyltransferase and glutamate dehydrogenase activities.This publication has 1 reference indexed in Scilit: