An interesting clinical picture characterized by slowly extending serpiginous and polycyclic lesions with raised edges, hyperkeratosis of the flexures, and hyperhidrosis of the palms, present from birth, in a woman aged 23, was first described by Comel,1in 1949. The back, abdomen, and proximal parts of the extremities were mainly involved; the condition became more pronounced at puberty, but there were subsequently some remissions. Comel suggested the term "ichthyosis linearis circumflexa." In a review of the literature we were able to find only one further case report under this diagnosis. Frank's2patient (1956), a man, showed almost identical clinical features. The condition had appeared within the first three months of life and had persisted. We believe that the cases presented by Miescher,3in 1954,