α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice
- 1 November 1992
- journal article
- Published by Springer Nature in Nature
- Vol. 360 (6402) , 313-319
- https://doi.org/10.1038/360313a0
Abstract
The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.Keywords
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